Supplements can treat PCOS (polycystic ovary syndrome)
Various supplements (inositol, vitex, etc.) can reverse PCOS symptoms
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Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome
Published 1999Reviewer Insight2/3/2026The study was funded by Insmed Pharmaceuticals (in addition to NIH funding)
- Dr. Nestler served as a consultant to Insmed Pharmaceuticals
- Three of the five researchers (Paula Reamer, Ronald D. Gunn, Geoffrey Allan) were affiliated with Insmed Pharmaceuticals
- Insmed held a patent on DCI for PCOS treatment obtained in 1998, before this 1999 study was published
- The company studied stood to directly benefit from positive findings showing D-chiro-inositol treats PCOS.
- Limited Tested in Humans
A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome
Published 2012Reviewer Insight2/3/2026Key Findings:
- Berberine Improves Lipid Profiles and Dyslipidemia (Key PCOS Complication)
- Berberine Improves Insulin Sensitivity (Core PCOS Dysfunction)
Summary of Major Limitations:
- Small sample size with unknown dropout rate
- Blinding procedures not documented
- Concomitant anti-androgen medication confounds the results
- Short-term intervention (3 months only)
- Limited to women with insulin-resistant PCOS phenotype
- Baseline confounding variables not clearly documented
- Awaiting Review
Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
Published 2023 - Awaiting Review
The Role of Zinc in Selected Female Reproductive System Disorders.
Published 2020
Snapshot built: 2026-06-19