Oxygen therapy for sleep issues in Parkinson's disease

This meta-analysis of 7 Chinese trials (461 patients) found that hyperbaric oxygen therapy combined with Parkinson's medication (Pramipexole) significantly improved sleep compared to medication alone: patients slept 57-76 minutes longer, woke up 10 fewer times, and reported better sleep quality. However, none of the studies were blinded, which could bias results. Studies **were also short (2 months only) **and limited to Chinese populations, so long-term benefits and generalizability are uncertain. Recommendations: Future research needs blinded trials with sham oxygen chambers, longer follow-up (6-12 months), diverse populations beyond China, comparison with other PD medications, distinction between sleep disorder types, cost-effectiveness analysis, and systematic safety monitoring to establish whether these benefits are real, sustainable, and applicable to broader patient populations.