Omega-3 fatty acids reduce risk of cardiovascular events like heart attack and stroke
Two main omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found mainly in fish and fish oil. Omega-3s from fish and fish oil have been recommended by the American Heart Association (AHA) for the past 20 years to reduce cardiovascular events
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Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
Published 2019Reviewer Insight12/9/2025Mostly white males in study - 90% white, 70% makle Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial (REDUCE-IT) Trial. EPA was administered in patients and compared to placebo
- Tested in Humans
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
Published 2007Reviewer Insight12/9/2025Only in Japanese population Eligibility criteria were total cholesterol concentration of 6·5 mmol/L or greater, which corresponded to a LDL cholesterol of 4·4 mmol/L or greater. Interestingly, higher proportion of women in the study (postmenopausal up to age 75)
- Tested in Humans
Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk
Published 2020Reviewer Insight12/9/2025The study design was well thought out across multiple sites and statistics were appropriate
Snapshot built: 2026-06-19