Metabolic rate declines across the menopause transition due to changes in estrogen
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A narrative review of energy expenditure and substrate oxidation during menopause
Published 2026Reviewer Insight3/30/2026This is a review study and it is not valid to support a claim in our platform. We will search for references that we can review.
- Tested in Humans
Daily energy expenditure through the human life course
Published 2021Reviewer Insight3/30/2026Metabolic rate does not decline during menopause years: In this large study of 6,421 people across 29 countries, energy expenditure was completely flat from ages 20 to 60 — the entire window when menopause occurs — in both men and women
The decline happens after 60, and in both sexes: When metabolic rate does eventually drop, it starts around age 63 and occurs equally in males and females, pointing to general aging processes rather than estrogen loss
Not designed to study menopause: This study did not measure hormone levels or menopausal status, and was not longitudinal — it cannot directly test whether estrogen drives any metabolic changes within individuals across the transition
Bottom line: A study of 6,000+ people finds no metabolic decline during the menopause window, and the decline that does occur after 60 affects both sexes equally, contradicting the idea that estrogen changes during menopause are responsible
Snapshot built: 2026-06-19