The Health Integrity Project
Inconclusive

Menopause accelerates muscle loss

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  • Inconclusive

    Changes in body composition and weight during the menopause transition

    Published 2019
    Reviewer Insight
    1/6/2026

    This observational study has the inherent limitation of being unable to establish causation. It specifically addresses body composition changes during the menopausal transition and finds a slight increase in lean mass loss around the time of final menstruation compared to before and after. The underlying cause is difficult to determine since this period may be confounded by other transition-related factors like sleep disturbances, anxiety, and gastrointestinal issues. Despite these limitations, this is a solid study showing a possible correlation. The findings also reveal racial differences, with White and Japanese women showing greater lean mass loss.

  • Inconclusive

    Changes in physical activity and body composition in postmenopausal women over time

    Published 2013
    Reviewer Insight
    11/6/2025

    This study is very well done but it doesn’t address the menopause transition as a factor for loss or not of lean mass, so the result of loss on body mass can be associated to aging and menopause transition at the same time since all women will go through that period.

  • Invalid

    Systematic review on the relationship between menopausal hormone replacement therapy, sarcopenia, and sarcopenia-related parameters

    Published 2025
    Reviewer Insight
    1/6/2026

    This paper reviews and synthesizes 43 other studies (15 RCTs and 28 observational studies) about HRT and sarcopenia. The authors state: "Initially, we hoped to perform meta-analysis of the RCTs ... Heterogeneity was extremely high...". Results are "synthesised and are presented narratively". Due to this fact, we will add the most important paper for this review to evaluate the evidence.

  • Awaiting Review

    Effects of non-pharmacological interventions on body composition and physical function in older women with sarcopenic obesity: a meta-analysis.

    Published 2025
  • Awaiting Review

    The effect of chair-based exercise on physical functioning in postmenopausal women: a meta-analysis.

    Published 2025

Snapshot built: 2026-06-19