Liposomal TMG supports performance, recovery, and body composition and normal liver fat metabolism
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Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis
Published 2013Reviewer Insight3/23/2026Paper studies the wrong outcomes: This study only measured plasma homocysteine levels — it says nothing about performance, recovery, body composition, or liver fat metabolism
Liposomal form not tested: All studies used standard betaine supplementation — liposomal delivery was never evaluated
Liver fat note: The paper does mention betaine's role in liver BHMT enzyme activity (up to 50% of homocysteine metabolism) and notes betaine may affect VLDL lipid export from the liver — but this is a mechanistic side note, not a studied outcome
Bottom line: This meta-analysis is focused on that TMG lowers homocysteine in healthy adults, but it does not support claims about performance, recovery, body composition, or liver fat metabolism
- Inconclusive
Effect of Homocysteine-Lowering Nutrients on Blood Lipids: Results from Four Randomised, Placebo-Controlled Studies in Healthy Humans
Published 2005Reviewer Insight3/24/2026Study not designed for this claim: This study measured blood cholesterol and triglycerides — not athletic performance, recovery, or body composition, which are the main focus of the claim
Dose mismatch: The betaine dose tested (6 g/d) is higher than what most TMG supplements provide (typically 0.5–3 g/d) — lower doses showed trends but no statistically significant lipid changes
Liver fat signal worth noting: Betaine at high doses appears to increase fat export from the liver into the blood (raising LDL by ~11% and triglycerides by ~13%), which raises questions about the "normal liver fat metabolism" part of the claim
Bottom line: This study cannot confirm or refute most of the claim, but raises a cautionary flag about betaine's effect on blood lipids at high doses — classified as Inconclusive due to dose mismatch and mismatched outcome measures
- Awaiting Review
Systematic profiling reveals betaine as an exercise mimetic for geroprotection
Published 2025 - Awaiting Review
Betaine supplementation fails to improve body composition: a systematic review and meta-analysis
Published 2021
Snapshot built: 2026-06-19