Hormone therapy prevents muscle loss in postmenopausal women
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Association Between Hormone Therapy and Muscle Mass in Postmenopausal Women
Published 2019Reviewer Insight4/26/2026- Overall finding contradicts the claim: This high-quality analysis of 12 clinical trials found that hormone therapy did not significantly preserve muscle mass in postmenopausal women — the average difference was just 0.06 kg (about the weight of a small coin), which was not statistically significant
- One subgroup showed a positive signal, but it's unreliable: Estrogen-only therapy showed a borderline significant effect, but the studies in this subgroup were so inconsistent with each other (I² = 84%) that the result cannot be trusted — and it would not survive correction for multiple statistical tests
- Bottom line: The best available evidence from clinical trials does not support the claim that hormone therapy prevents muscle loss in postmenopausal women
- Awaiting Review
Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy.
Published 2001 - Awaiting Review
Oral low-dose testosterone administration induces whole-body protein anabolism in postmenopausal women: a novel liver-targeted therapy.
Published 2013
Snapshot built: 2026-06-19