Grip strength is a biomarker for longevity

• Initial study sample of n = 14781; after an 8-year follow-up assessment in 2014/2016 the final cohort of n = 1275
• normalized grip strength asscoaution with DNAm biological clocks (three different ones)
• Differences observed with different clocks in male and female; future studies should include sex-stratified models to inform potential differences in ageing indicators by sex.

This study identifies risk and association. In people of diverse economic and sociocultural backgrounds, grip strength is a strong predictor of cardiovascular mortality and a moderately strong predictor of incident cardiovascular disease.

Very thorough analysis and stratification of cohorts. The Prospective Urban-Rural Epidemiology (PURE) study is a prospective cohort study of more than 154 000 community-based individuals from 17 high-income, middle-income, and low-income countries.